Cos-mic - The Cancer Mutation Census (CMC) project is an undertaking to classify coding mutations in COSMIC and identify variants driving different types of cancer. The CMC integrates all coding somatic mutations collected by COSMIC with biological and biochemical information from multiple sources, combining data obtained from manual curation and computational …

 
The table shows the distribution of mutations across the primary tissue types that are curated by COSMIC. Histograms show the percentage of mutated samples for point mutations, CNV data and gene expression data. Moving your mouse over the histograms will show additional data. The number of samples tested on this page include samples …. Circus circus map

The ori­gin of Cos­mic Rays. 22.04.2024. New results from Gamma-ray astronomy contrast the decade-old standard paradigm for the origin of Galactic cosmic …b, Fraction of somatic SNVs detected in epithelial cells attributed to COSMIC signatures. SBS signatures associated with ultraviolet radiation (SBS7a, SBS7b, SBS7c and SBS7d) and clock-like ...The table shows the distribution of mutations across the primary tissue types that are curated by COSMIC. Histograms show the percentage of mutated samples for point mutations, CNV data and gene expression data. Moving your mouse over the histograms will show additional data. The number of samples tested on this page include samples …The light blue band demonstrates the cosmic variance expected for the model; this is a measure of how likely random chance of our positon relative to other matter in the universe is affecting the results. The Universe Content: the Ingredients. There are three ingredients in this universe: normal matter (or atoms), cold dark matter, and dark … At Cos-Mic 2023, where the stars of entertainment align in a spectacular showcase! Secure Your Spot in the Stars: Tickets are flying fast! Grab yours and ensure your place in this interstellar celebration of talent and creativity. Stay Informed: Keep in mind, the universe is ever-changing, and so is our schedule. COSMIC Curated Genes & Fusions COSMIC contains curated somatic mutation data from the scientific literature, the Cancer Genome Project's systematic screens, and data from the ICGC and TCGA.. The first 3 tabs on this page summarise important cancer genes (curated and cancer census genes) and the 4th tab ('All genes') allows all COSMIC genes to be … Find 31 different ways to say COSMIC SPACE, along with antonyms, related words, and example sentences at Thesaurus.com. ‘COSMIC whole genomes’ displays only the genome-wide tumor analyses integrated into COSMIC, providing a view across the breadth of cancer genome data without any specific biases introduced via literature curation. ‘COSMIC’ displays all the data brought into the system across the project's life, including cell lines, whole genomes and …Cos-Mic 2023 will take place at Sunway Pyramid Convention Centre from 3 to 5 November 2023. Visit the Cos-Mic Facebook page for more updates. Listen to the My Cos-Mic song below. Aka Akasaka anime anime adaptation Cos-Mic 2023 Cos-Mic 2023 Malaysia idol j-pop Netflix Oshi no Ko Oshi no Ko anime Ruby Hoshino Sarina Tendouji …The table shows the distribution of mutations across the primary tissue types that are curated by COSMIC. Histograms show the percentage of mutated samples for point mutations, CNV data and gene expression data. Moving your mouse over the histograms will show additional data. The number of samples tested on this page include samples …Most of the energetic cosmic ray particles —mainly protons —have galactic origin, some of them enter the solar system and bombard the Earth’s atmosphere. …Cosmic radiation. A source of natural background radiation, which originates in outer space and is composed of penetrating ionizing radiation (both particulate and electromagnetic). The sun and stars send a constant stream of cosmic radiation to Earth, much like a steady drizzle of rain. Differences in elevation, atmospheric conditions, and …The signatures in COSMIC v.2 had a median cosine similarity of 0.238. By contrast, the current signatures have a much lower median cosine similarity of 0.098.The table shows the distribution of mutations across the primary tissue types that are curated by COSMIC. Histograms show the percentage of mutated samples for point mutations, CNV data and gene expression data. Moving your mouse over the histograms will show additional data. The number of samples tested on this page include samples … Cos-Mic. cos-mic, The Universe of Possibilities Established in 2021, Cos-Mic, a subsidiary of DBS ASIA, is a Malaysian entertainment company specializing in managing diverse brands and IPs. We aim to shape the industry with creativity and digital excellence, curating campaigns and events that offer quality experiences. Our mission is to enrich ... Jan 28, 2022 · The cosmic microwave background (CMB) is leftover radiation from the Big Bang or the time when the universe began. As the theory goes, when the universe was born it underwent rapid inflation ... COSMIC is built primarily via curation of published literature by expert scientists. This is still a major focus, and as this team expands, COSMIC has been able to encompass greater breadth of annotations, recently resulting in the new focus on Genetics of Drug Resistance. All aspects of cancer genetic curation will continue, with an …He had discovered cosmic rays. These high-energy particles arriving from outer space are mainly (89%) protons – nuclei of hydrogen, the lightest and most common element in the universe – but they also include nuclei of helium (10%) and heavier nuclei (1%), all the way up to uranium. When they arrive at Earth, they collide with the nuclei of ...There's an issue and the page could not be loaded. Reload page. 9,824 Followers, 0 Following, 218 Posts - See Instagram photos and videos from Cos-mic (@cosmic_asia)Universe. At CosMc’s, you'll find exactly what you need to take you to your happy place. And you'll feel rejuvenated by more than just a drink. We know that everyday life can …The universe has experienced two distinct periods of cosmic acceleration. The first, called inflation, occurred a fraction of a second after the Big Bang. The second is the extended period of cosmic acceleration that began about 9 billion years after the Big Bang and continues today. Scientists discovered the increasing expansion of the ...Gene fusions. ABL1 is involved in 3 fusions, with the following genes: BCR (5483 mutations in 8847 samples) NUP214 (45 mutations in 873 samples) ETV6 (32 mutations in 811 samples) Drug sensitivity data. Mutations in ABL1 are associated with altered sensitivity to the following drug: Luminespib. See all drug sensitivity data for ABL1.The table shows the distribution of mutations across the primary tissue types that are curated by COSMIC. Histograms show the percentage of mutated samples for point mutations, CNV data and gene expression data. Moving your mouse over the histograms will show additional data. The number of samples tested on this page include samples …The table shows the distribution of mutations across the primary tissue types that are curated by COSMIC. Histograms show the percentage of mutated samples for point mutations, CNV data and gene expression data. Moving your mouse over the histograms will show additional data. The number of samples tested on this page include samples …There are 3 ways COSMIC data can be downloaded: Download in Browser, Scripted Downloads, and Filtered downloads. To access any of these options, select the release version and the product you want to download (e.g. Breakpoints, Cancer Gene Census), and click on the 'File Name'. This will open up a pop-up window with the 3 options …Apr 16, 2024 · cosmic laws. 2. characteristic of the cosmos or its phenomena. cosmic events. 3. immeasurably extended in time and space; vast. 4. forming a part of the material universe, esp. outside of the earth. Also: cosmical SYNONYMS 3. immense, enormous, stupendous. Participants in deep space missions face protracted exposure to galactic cosmic radiation (GCR). In this setting, lung cancer is a significant component of the overall risk of radiation-exposure ...McDonald's has not announced what will be on the CosMc's menu. However, Chicago-area real estate investor Iman Jalali claims to have captured images of a menu board outside an upcoming CosMc's in ...This glow, still detectable today, is called the cosmic microwave background. It is the oldest light we can observe in the universe. Scientists used nine years of data from NASA’s Wilkinson Microwave Anisotropy Probe to create this detailed, all-sky image of the cosmic microwave background. The image reveals 13.8-billion-year-old temperature ...Import the ID field containing the stable COSMIC ID of each cancer-related mutation and the info field named ‘CNT’ that represents the number of cancer samples presenting this specific mutation. Find 31 different ways to say COSMIC SPACE, along with antonyms, related words, and example sentences at Thesaurus.com. shipping policy shipping/fulfulment policy This policy outlines the terms and conditions relating to the delivery and fulfilment of goods and services from us and/or the third-party suppliers/providers to you. Your usage of our Application shall be deemed as your acknowledgment and agreement to the terms of this policy. Shipment availability We, …COSMIC definition: 1. relating to the universe and the natural processes that happen in it: 2. very great: 3…. Learn more.The light blue band demonstrates the cosmic variance expected for the model; this is a measure of how likely random chance of our positon relative to other matter in the universe is affecting the results. The Universe Content: the Ingredients. There are three ingredients in this universe: normal matter (or atoms), cold dark matter, and dark …BOLINGBROOK, Ill. -- McDonald's new secretive spin-off restaurant, CosMc's, appears to be close to opening a location in a suburb just outside of Chicago. Our sister station's helicopter was over ...The gene view histogram is a graphical view of mutations across APC. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left.COS-MIC 2023 Malaysia. COS-MIC 2023 isn't just a pop culture event; it's a celebration of everything we love, cherish, and get excited about. From comics to movies, art, music, and beyond – if it's in pop culture, it's here. This epic event is happening from November 3 to 5, 2023 at the Sunway Pyramid Convention Center in Malaysia.The gene view histogram is a graphical view of mutations across AR. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left.Definition of cosmic adjective in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more.COSMIC Mutational Signatures version 3.4 is the latest release. Version 3 was released as part of COSMIC release v89 (May 2019), updated to version 3.1 in COSMIC release v91 (June 2020), to version 3.2 in COSMIC release v93 (March 2021), to version 3.3 in COSMIC v95 (May 2022) and most recently version 3.4 in COSMIC v98. …Below you can find the BEST Pet Simulator X Value List. We update our values daily with the new prices. There are over 400+ items. Check our new Pet Simulator 99 values & …At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.The gene view histogram is a graphical view of mutations across ATM. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left.Official Pet Simulator 99 Value List. Your source for Pet Sim 99 values, including Titanic Pets, Huge Pets, Exclusives, Misc Items, Stat Pets, Glitched Pets, Shiny Pets, Misc …BOLINGBROOK, Ill. -- McDonald's new secretive spin-off restaurant, CosMc's, appears to be close to opening a location in a suburb just outside of Chicago. Our sister station's helicopter was over ...More details of the paper can be found by following the ‘COSMIC link’ or ‘Pubmed Link’. This table also provides the ability to search, sort and export the table in csv or tsv format. Reference Title - The abbreviated title of the article. Mouseover the title to see the full article title. Author – First author (s) of the publication, to see all authors of the publication …The Truth 2.0 out here https://blackhole.lnk.to/thetruth2Cosmic Gate have ticked another next-level livestream off their wish-list! After streaming sets from...Apr 5, 2024 · Cosmic microwave background (CMB), electromagnetic radiation filling the universe that is a residual effect of the big bang 13.8 billion years ago. Because the expanding universe has cooled since this primordial explosion, the background radiation is in the microwave region of the electromagnetic spectrum. COSMIC is now integrating this information into the database, providing full coding and genomic variant annotations for samples, both from CGP laboratories and recent publications. DATABASE CONTENT. For years, the COSMIC database has described somatic mutations in key cancer genes across many cancer samples, and, …COSMIC (Ghosal et al. 2020a) introduces commonsense knowledge, such as mental states and causal relations to support ERC. GRUs are used to encode the knowledge. DialogXL (DiXL) (Shen et al. 2021a ...Import the ID field containing the stable COSMIC ID of each cancer-related mutation and the info field named ‘CNT’ that represents the number of cancer samples presenting this specific mutation.COSMIC is built primarily via curation of published literature by expert scientists. This is still a major focus, and as this team expands, COSMIC has been able to encompass greater breadth of annotations, recently resulting in the new focus on Genetics of Drug Resistance. All aspects of cancer genetic curation will continue, with an …Updated design for COSMIC Mutational Signatures landing page. New preview of the mutational signature profiles, including proposed aetiologies. New website for SigProfiler tools With a few exceptions, the new v3.1 signatures were extracted using SigProfiler. We now provide a specific website for this comprehensive and integrated … cosmic: 1 adj of or from or pertaining to or characteristic of the cosmos or universe “ cosmic laws” “ cosmic catastrophe” “ cosmic rays” adj inconceivably extended in space or time Synonyms: big , large above average in size or number or quantity or magnitude or extent The 20,000-light-year-long fountain of gas is moving at 450 times the top speed of a jet fighter. Comments (1) The galaxy NGC 4383 evolves as gas flows from its …Mutational landscape of cancer genes in human cancers. Our study compiled a list of 727 known cancer genes based on information from the Catalogue of Somatic Mutations in Cancer (COSMIC) 24 and ...Apr 16, 2024 · Synonyms for COSMIC in English: extraterrestrial, stellar, universal, general, omnipresent, all-embracing, overarching, vast, huge, immense, … If you have questions about our food, please reach out to us directly using our contact us forms. Tour CosMc’s menu of otherworldly beverage creations, pick-me-ups, coffees, teas, lemonades, sandwiches, tasty treats, and more. October 29 at 7:52 PM ·. Cos-Mic 2023 is coming to Sunway Pyramid Convention Center! Get ready, everyone! From 3rd to 5th November 2023, Sunway Pyramid Convention Center will transform into the epicenter of pop culture in Malaysia. Join the vibe as international artists take the stage for unforgettable performances. But that's not all! COSMIC comprises a number of subtly different data domains. Ninety percent of the mutation content adheres to the original goal of curating the world’s literature on known cancer genes. However, with the speed of DNA sequencing accelerate rapidly, tumour analysis is becoming less focused on single genes and it is not unusual to find …The Cosmic Ocean Reveals Brahma, Vishnu and Shiva (opaque watercolor and gold on paper, San Diego Museum, 1835). A cosmic ocean, primordial waters, or celestial river is a mythological motif that represents the world or cosmos enveloped by a vast primordial ocean. Found in many cultures and civilizations, the cosmic ocean exists before the …cosmic: [adjective] of or relating to the cosmos, the extraterrestrial vastness, or the universe in contrast to the earth alone. of, relating to, or concerned with abstract spiritual or metaphysical (see metaphysical 2) ideas.The 20,000-light-year-long fountain of gas is moving at 450 times the top speed of a jet fighter. Comments (1) The galaxy NGC 4383 evolves as gas flows from its …Cosmic ray particles are very dangerous to people and machines. That’s because cosmic ray particles travel at high speeds and have high energy. On Earth,we are protected from primary cosmic rays by Earth's magnetosphere (magnetic field) and atmosphere. To some degree, astronauts and machines are also protected by these things in low-Earth ... cosmic microwave background radiation: 1 n (cosmology) the cooled remnant of the hot big bang that fills the entire universe and can be observed today with an average temperature of about 2.725 kelvin Synonyms: CBR , CMB , CMBR , cosmic background radiation , cosmic microwave background Type of: cosmic radiation radiation coming from outside ... COSMIC-3D integrates cancer mutations with protein structures across the human genome and structural proteome. Our unique combination of protein structure, mutation location/recurrence, and druggability predictions presents a vital tool for precision medicine, enabling high-resolution mutation-guided drug discovery. Get started now.Import the ID field containing the stable COSMIC ID of each cancer-related mutation and the info field named ‘CNT’ that represents the number of cancer samples presenting this specific mutation.Cos-Mic 2023 will take place at Sunway Pyramid Convention Centre from 3 to 5 November 2023. Visit the Cos-Mic Facebook page for more updates. Listen to the My Cos-Mic song below. Aka Akasaka anime anime adaptation Cos-Mic 2023 Cos-Mic 2023 Malaysia idol j-pop Netflix Oshi no Ko Oshi no Ko anime Ruby Hoshino Sarina Tendouji …Universe. At CosMc’s, you'll find exactly what you need to take you to your happy place. And you'll feel rejuvenated by more than just a drink. We know that everyday life can …Whole-genome sequencing screens are now identifying large numbers of genomic rearrangements in cancer and COSMIC is now displaying details of these analyses also. Examination of COSMIC's data is primarily web-driven, focused on providing mutation range and frequency statistics based upon a choice of gene and/or cancer phenotype.Universe. At CosMc’s, you'll find exactly what you need to take you to your happy place. And you'll feel rejuvenated by more than just a drink. We know that everyday life can weigh us down.Muat Turun Cos-Mic App dari App Store atau Google Play. Dafter; Pilih acara Cos-Mic 2023; Buat pembelian tiket; Lepas selesai buat pembelian, boleh dapatkan gelang di booth penebusan bertempat di Blue Atrium Sunway Pyramid pada hari kejadian dan penebusan boleh dilakukan bermula 31 Oktober sehingga 5 November! Untuk …Whether you love gaming, music, anime, dressing up, or just exploring, Cos-Mic 2024 is the place to be. 📅 Mark Your Calendars: September 14th, 15th, 16th, 2024 📍 Where: Sunway Pyramid Convention Center Keep an eye out for more updates on our guest lineup, workshops, and special events that will make this year’s Cos-Mic …Hey friends it's been a while again XD. I'm very excited to announce a collaboration with Cos-Mic, a well-established pop culture event in Malaysia, along wi...Gene fusions. ABL1 is involved in 3 fusions, with the following genes: BCR (5483 mutations in 8847 samples) NUP214 (45 mutations in 873 samples) ETV6 (32 mutations in 811 samples) Drug sensitivity data. Mutations in ABL1 are associated with altered sensitivity to the following drug: Luminespib. See all drug sensitivity data for ABL1.A list of cancer drivers was obtained from the COSMIC Cancer Census database (Version Dec 21 23_46_30 2022) 44 Genes were classified based on the disease where they have been reported to the ...Cosmic Manipulation. The Silver Surfer (Marvel Comics) possesses a fraction of the Power Cosmic, a source of ambient cosmic energy permeating the universe that makes possible the channeling and manipulation of energy. Power/Ability to: Control cosmic forces. "You may have some of the power of the saints, but you use it only for destruction. There's an issue and the page could not be loaded. Reload page. 9,824 Followers, 0 Following, 218 Posts - See Instagram photos and videos from Cos-mic (@cosmic_asia) Whether you love gaming, music, anime, dressing up, or just exploring, Cos-Mic 2024 is the place to be. 📅 Mark Your Calendars: September 14th, 15th, 16th, 2024 📍 Where: Sunway Pyramid Convention Center Keep an eye out for more updates on our guest lineup, workshops, and special events that will make this year’s Cos-Mic …Tier 1 genes have documented evidence of their relevance to cancer. Curated gene. This is an expert curated gene . Mouse gene. Mouse insertional mutagenesis experiments support the designation of RB1 as a cancer causing gene. More information. Hallmark gene. This gene has a cancer hallmark . You can see more information about hallmarks.This event will take place at Sunway Clio Exhibition Centre and will be held from 24th to 26th June from 10 am – 7 pm. Our Cos-mic event gives an opportunity for Doujin related to Anime, Artwork and Cosplayers to showcase their newest products or arts and illustrations. For the attendees of the event, it obviously will give thousands of ...The CMB is visible at a distance of 13.8 billion light years in all directions from Earth, leading scientists to determine that this is the true age of the Universe. However, it is not an ...d COSMIC cancer signature 6 (linked to MMR deficiency; left) is significantly similar to profiles from lung samples expressing low levels of MLH1 (right). The plot in the left panel represents the frequency of C>T mutations at the indicated tri-nucleotide context for signature 6. The plot in the right panel is the log ratio of C>T mutation rates …COSMIC can accommodate information on base substitutions, insertions and deletions, translocations and changes in copy number. For the four genes presently in COSMIC, there are 147Official Pet Simulator 99 Value List. 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Jun 20, 2022 · The Cos-Mic Cosplay & Doujin Fair will be celebrating all things geeky at the Sunway Clio Exhibition Centre this weekend from 25 to 26 June 2022, with plenty of activities and performances to keep you entertained all weekend. Best of all, admission to the event is completely FREE for everyone. You can stay tuned on their official Facebook page ... . Sober counter

cos-mic

If you have questions about our food, please reach out to us directly using our contact us forms. Tour CosMc’s menu of otherworldly beverage creations, pick-me-ups, coffees, teas, lemonades, sandwiches, tasty treats, and more.COSMIC-2 data processed operationally in near-real time ar. e published daily by 0200 UTC the following day at ...d COSMIC cancer signature 6 (linked to MMR deficiency; left) is significantly similar to profiles from lung samples expressing low levels of MLH1 (right). The plot in the left panel represents the frequency of C>T mutations at the indicated tri-nucleotide context for signature 6. The plot in the right panel is the log ratio of C>T mutation rates …Jun 20, 2022 · The Cos-Mic Cosplay & Doujin Fair will be celebrating all things geeky at the Sunway Clio Exhibition Centre this weekend from 25 to 26 June 2022, with plenty of activities and performances to keep you entertained all weekend. Best of all, admission to the event is completely FREE for everyone. You can stay tuned on their official Facebook page ... This glow, still detectable today, is called the cosmic microwave background. It is the oldest light we can observe in the universe. Scientists used nine years of data from NASA’s Wilkinson Microwave Anisotropy Probe to create this detailed, all-sky image of the cosmic microwave background. The image reveals 13.8-billion-year-old temperature ...Import the ID field containing the stable COSMIC ID of each cancer-related mutation and the info field named ‘CNT’ that represents the number of cancer samples presenting this specific mutation.McDonald's could lean into CosMc's outer space, high-tech lineage as a theme for the new restaurants it wants to test. "CosMc’s is a small format concept with all the DNA of McDonald’s but its ...Muat Turun Cos-Mic App dari App Store atau Google Play. Dafter; Pilih acara Cos-Mic 2023; Buat pembelian tiket; Lepas selesai buat pembelian, boleh dapatkan gelang di booth penebusan bertempat di Blue Atrium Sunway Pyramid pada hari kejadian dan penebusan boleh dilakukan bermula 31 Oktober sehingga 5 November! Untuk …Dec 6, 2023 · Published 5:22 PM EST, Wed December 6, 2023. Link Copied! McDonald's starts testing CosMc’s in Bolingbrook, Illinois this week. Courtesy McDonald's. New York CNN —. Shedding light on its long ... 1.0.7. Cos-Mic. Download APK (16 MB) Step into a world with Cos-Mic for an unique experience . Description Lifestyle. Advertisement. He had discovered cosmic rays. These high-energy particles arriving from outer space are mainly (89%) protons – nuclei of hydrogen, the lightest and most common element in the universe – but they also include nuclei of helium (10%) and heavier nuclei (1%), all the way up to uranium. When they arrive at Earth, they collide with the nuclei of ... Participants in deep space missions face protracted exposure to galactic cosmic radiation (GCR). In this setting, lung cancer is a significant component of the overall risk of radiation-exposure ... There's an issue and the page could not be loaded. Reload page. 9,824 Followers, 0 Following, 218 Posts - See Instagram photos and videos from Cos-mic (@cosmic_asia) Synonyms and analogies for "cosmic" in English grouped by meanings. Translation Context Grammar Check Synonyms Conjugation. Apr 11, 2022 · Figure 29.4.1 29.4. 1 Cosmic Microwave Background and Clouds Compared. (a) Early in the universe, photons (electromagnetic energy) were scattering off the crowded, hot, charged particles and could not get very far without colliding with another particle. But after electrons and photons settled into neutral atoms, there was far less scattering ... Terms ANd conditions Terms of usage Upon registration of your user account, it shall be deemed that you have fully understood, acknowledged and agreed to the terms and conditions of usage hereinafter set forth. In using our Application, you risk your account being suspended, terminated, removed or banned without prior notice to you if itMcDonald's has not announced what will be on the CosMc's menu. However, Chicago-area real estate investor Iman Jalali claims to have captured images of a menu board outside an upcoming CosMc's in ...COSMIC Mutational Signatures version 3.4 is the latest release. Version 3 was released as part of COSMIC release v89 (May 2019), updated to version 3.1 in COSMIC release v91 (June 2020), to version 3.2 in COSMIC release v93 (March 2021), to version 3.3 in COSMIC v95 (May 2022) and most recently version 3.4 in COSMIC v98. ...cosmic X-ray background, X-ray radiation pervading the universe. In 1962 the first X-ray detectors were flown above Earth’s X-ray-absorbing atmosphere in a sounding rocket. In addition to discovering the first …The gene view histogram is a graphical view of mutations across ATM. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left..

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